The Non-Hormonal Protocol

For when HRT isn't an option, or isn't your choice. Here is the evidence-backed alternative path.

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The Landscape

Not every woman can take Hormone Replacement Therapy. For those with a history of certain estrogen-receptor-positive cancers, blood clots, or specific cardiovascular risks, HRT is contraindicated. Other women simply prefer not to use hormonal interventions.

The non-hormonal landscape is unfortunately crowded with expensive supplements lacking clinical data. This protocol filters out the noise, focusing only on interventions with demonstrated efficacy in peer-reviewed studies.

Clinical Alternatives

It is important to know that there are non-hormonal prescription medications that are highly effective for specific symptoms:

• Veozah (fezolinetant): A newer FDA-approved non-hormonal prescription specifically targeting the brain receptors responsible for hot flashes.
• SSRIs/SNRIs: Certain low-dose antidepressants (like paroxetine or venlafaxine) have been shown to significantly reduce hot flashes and stabilize mood lability.
• Gabapentin: Another prescription option often used off-label for severe vasomotor symptoms.

These require a physician's prescription and are used under physician guidance. You can discuss these specific non-hormonal options with a specialized provider.

The Supplement Protocol

When looking at over-the-counter interventions, the focus must be on high-quality, bioavailable forms of specific compounds.

For the Foundational Stack (Peri & Postmenopause):

For women who want one evidence-aligned starting point instead of five separate decisions, Momentous offers a peri and post-menopause stack — creatine, collagen peptides, turmeric, Alpha GPC, and vitamin D3 — formulated with exercise physiologist Dr. Stacy Sims around the documented midlife depletions: creatine, collagen, and vitamin D.

For Sleep Architecture & Nervous System Regulation:

Magnesium is critical, but the form matters. Magnesium Glycinate is highly bioavailable and crosses the blood-brain barrier to support sleep and reduce anxiety.

For Cognitive Clarity (Brain Fog):

Omega-3 fatty acids (specifically high EPA/DHA ratios) support neuro-inflammation reduction and cognitive function.

For Hair & Skin Changes:

The hormonal shift impacts the hair growth cycle. Targeted, clinically tested nutraceuticals can support follicle health during this transition.